No. Research shows that UV light is not capable of achieving the necessary 6-log reduction in pathogens recommended for mattresses even on hard surfaces.43-46 The FDA has acknowledged that UV light is not effective on soft, porous surfaces such as hospital mattresses.47 Furthermore, UV light has been ineffective at decreasing C. diff rates in healthcare facilities.43,48,49 UV has also been shown to damage polymers used in healthcare facilities,19 such as the materials used to make mattress covers. Damage to the mattress cover could lead to fluid ingress to the mattress core, making disinfection impossible.
FOLLOW-UP: Ask your mattress manufacturer if they recommend using UV light for disinfection on the mattress or if it will cause damage to the polyurethane mattress surface.