Some mattress covers can be laundered to remove gross soil and blood. However, these are not meant to be removed and laundered between every patient, and they generally cannot be laundered using adequate concentrations of disinfectants or at a temperature high enough to kill C. diff. Furthermore, these covers do not provide protection to the bed deck, whereas the bed barrier does.
FOLLOW-UP: Ask the manufacturer for their laundry guidance to address C. diff.